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Symptoms related to folate deficiency include fatigue, apathy, insomnia, impaired concentration, and irritability ( The folate cycle is crucial for its role in the synthesis of S-adenosylmethionine (SAM) and the metabolism of vitamin B12 (66)

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In vitro glutathione peroxidase mimicry of ebselen is linked to its oxidation of critical thiols on key cerebral suphydryl proteins - A novel component of its GPx-mimic antioxidant mechanism emerging from its thiol-modulated toxicology and pharmacology

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