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The bioavailability of vitamin C is high at lower doses as shown below, but drops to less than 50% at higher doses

Other than that, glucotoxicity-activated ERS can mediate neuronal apoptosis and nerve tissue damage, thereby promoting DPN progression (104)

Onoda H, Inoue Y, Ezawa T, Murata I, Chantadee T, Limmatvapirat S et al (2020) Preparation and characterization of triamterene complex with ascorbic acid derivatives

It is is caracteristized by a prolonged exhaustion state, uneasily relieved by rest and often exacerbated by physical or intellectual effort and emotions

Flow cytometry analysis of peripheral neutrophils (CD45 + CD11b + Ly6G&Ly6C + ) and monocytes (CD45 + CD11b + Ly6G&Ly6C - ) from Gpx4 fl/fl ( c : n = 6, d : n = 10) and Gpx4 fl/wt LysMCre + (c: n = 9, d: n = 13) mice