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Description

Clin Cancer Res 2020, 26:10341044

The problem is the gap between preclinical data and clinical evidence

I said it could get very bad or not get bad

The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327329)