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In the present study, a widely targeted metabolomics approach based on ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used for what is considered to be the first time, coupled with multivariate and univariate statistical analyses, to assess the serum metabolic profile and potential pathway changes in patients with a COPD-FE phenotype

Sites at which AR was bound differentially in response to 0.06 nM R1881 (5245 up and 2 sites down) were all common to HD androgen (10 nM R1881

107 Hyperglycemia also disrupts the structure and function of the bloodbrain barrier (BBB) by inducing oxidative stress and secondary inflammatory responses, impairing brain function and the biosynthesis of neurotransmitters

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