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A decrease in flRAGE levels was observed in patients with impaired glucose tolerance and also diabetes, which was probably due to hyperglycemia-induced augmented proteolytic degradation of the RAGE subdomain mediated by disintegrins and metalloproteinases 10

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Disruption of this axis, often due to gut microbiome dysbiosis, leads to intestinal dysfunction and systemic inflammation

Recent advances in stimulus-responsive nanocarriers for gene therapy