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According to the in vitro and in vivo experiment results, the in vivo self-assembly and multivalent cooperative interactions could be intelligently and precisely realized, resulting in the amazing ferroptosis-based antitumor properties in multiple tumor models, which provides an alternative strategy for malignant tumor therapy

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Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R, Joint Task Force on Practice Parameters, Bernstein D, Blessing-Moore J, Khan D, Lang D, Nicklas R, Oppenheimer J, Portnoy J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Practice Parameter Workgroup, Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R (2014) Food allergy: a practice parameter update-2014

Among them, synovial macrophages (SMs) are known as the most prominent cells responsible for lesion formation and aggravation