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In an experimental autoimmune encephalomyelitis (EAE) model of MS, a high-fiber diet that boosts SCFA production expanded Foxp3 + Tregs, strengthened the gut barrier, and reduced CNS inflammation and disease severity [41]

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344 Iron overload may trigger an inflammatory response through activating the NF-B pathway and inducing the secretion of inflammatory factors such as IL-1, TNF-, and IL-6

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10.1136/gut.47.4.589 30 CristoforiF.DargenioV