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What the research actually says (and what it does not) Intellectual honesty demands acknowledging the limitations of current evidence

Oral administration is not effective because the peptide fragments are broken down in the digestive tract before they can reach systemic circulation

The results revealed that 347 genes were down-regulated and 573 genes were up-regulated following 1D228 treatment (Red dots indicate up-regulated genes in the group, blue dots indicate down-regulated genes in the group, and gray dots indicate non-significant differentially expressed genes)

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In clinical studies targeting obesity, particularly in the phase 3 trials based on the SURPASS program, tirzepatide demonstrated outstanding weight reduction benefits, with some patients achieving a weight loss of up to 22.5%