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Selective versus non-selective ROCK inhibitors need further examination for the treatment of pulmonary fibrosis

Cibinetide (ARA-290), by contrast, offers a more balanced, preventative approach via selective activation of the innate repair receptor (IRR), modulating inflammation without excessive suppressionmaking it potentially superior for long-term use and supporting muscle recovery while preserving the beneficial aspects of training-induced inflammation

They work by modulating cortisol, supporting GABA activity, and promoting calm alertness

Their mechanisms operate through different pathways (angiogenesis vs