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Frontiers in Physiology 2020, 10.3389/fphys.2020.00544

IGF-1 LR3 is a recombinant long-acting insulin-like growth factor-1 analog supplied for laboratory research use only

Telomeres, the protective caps of eukaryotic chromosomes, are highly susceptible to oxidative DNA damage, which can accelerate telomere shortening and, consequently, lead to premature senescence and genomic instability

Le Du F, Eckhardt BL, Lim B, Litton JK, Moulder S, Meric-Bernstam F, et al

However, under this condition, placental growth hormone may take this role as the prime regulator of maternal serum IGF-I during pregnancy[189], being of particular interest the positive expression of IGF-IR in placenta[190] and the lower expression of placental-derived IGF-I during IUGR[191]