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Most of these fibres travel through the stria medullaris thalami

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So although the hypothesis / reason for interest in these compounds is never explicitly stated, the thought process seems to be similar to David Harris thought process: pH-sensitive proteases are doing something, and here are two orthogonal ways to inactivate them

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This inspires the development of a supramolecular binary vesicle, which is composed of p -sulfonatocalix[4]arene and enzyme-cleavable myristoylcholine that undergoes enzyme-induced disassembly triggered by the cholinesterase, thereby enabling in vitro controlled release of the AD drug tacrine and demonstrating potential for targeted drug delivery (Guo et al., 2012)