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In general, mitochondrial ETC activity inhibits the occurrence of ferroptosis, as the former is essential for the activity of mitochondrial-localized Dihydroorotate Dehydrogenase (DHODH) [163] and Glycerol-3-Phosphate Dehydrogenase (GPD2) [164], both of which contribute to the production of reduced coenzyme Q and suppress ferroptosis

Figures were generated using Pymol ( Molscript 45 and Raster3D 46

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Although the C-terminal peptide was initially aggregating during HPLC purification, this peptide could be obtained employing an HPLC-free purification strategy, in which the desired peptide is linked to agarose beads and acetylated, truncated peptides are washed off, as they are not reacting with the beads (Figs