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(IV) Although many researchers have devoted themselves to uncovering the precise mechanisms of ferroptosis and have made some achievements, the existing studies mostly focused on the upstream pathways of lipid peroxidation, leaving largely unexplored the downstream molecular pathways or key molecular junctions after the initiation of ferroptosis

Ang II activates a number of signaling pathways in cells, including serine/threonine kinase, ERK, JNK/MAPK, and PKC [15] and has been proven in studies to elevate cytokines (IL-6, TNF-, and others), oxidative damage caused by ROS, endothelial injury caused by blocking NO generation, and vasoconstriction

However, whether this is due to the antioxidant capabilities of the foods, or the polyphenolics is a point of contention

USA 105 , 63806385 (2008)

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