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These substitutions were capable of altering the specificity of individual substrates for their cognate kinases in predictable ways, an effect that was driven largely, but not completely, by alteration of the K M values (Extended Data Fig

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These layers facilitate the mixing of nutrients through convection currents, where warmer, less dense water rises, while colder, denser water sinks

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232,233 In addition to pathways involved in iron metabolism, several other molecular pathways have also been implicated in ferroptosis, including the guanosine triphosphate cyclohydrolase 1/tetrahydrobiopterin (GCH1/BH4) axis, 234 the cysteine/glutathione/glutathione peroxidase 4 (GSH/GPX4) axis, 235,236 and the ferroptosis suppressor protein 1/coenzyme Q (FSP1/CoQ) axis