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This in vivo and in vitro effect was dependent on HIF-1 activation, since the protective effect was offset by the synergistic use of YC-1, a selective inhibitor of HIF-1

These electrons are then shuttled to ubiquinone (Q), reducing it to ubiquinol (QH_2)

10.1093/eurheartj/ehaa352 102

10.3389/fcell.2020.615131 Front Cell Dev Biol

In aerobic respiration, the final oxidant is molecular oxygen, which accepts four electrons from an electron donor such as NADH to be converted to water