Prebiotics have shown positive effects on anthropometric parameters, FPG, and CRP levels in women with PCOS ( Synbiotics are combinations of probiotics and prebiotics designed to enhance the survival of beneficial bacteria in the gut ( Overall, improved hormonal indices such as the free androgen index (FAI) and sex hormone-binding globulin (SHBG) are possible with probiotics, prebiotics, and synbiotics, as well as the regulation of inflammatory markers such as nitrogen oxide (NO) and MDA ( 7 Other supplements in PCOS CoQ 10 , an antioxidant, has been shown to be effective in women with PCOS who underwent assisted reproductive technologies (ART) ( The significant reduction in body weight and BMI associated with cinnamon demonstrates its effect on anthropometric indices in women with PCOS ( Recently, the potential role of Cr supplementation has received increasing consideration in improving or preventing PCOS (65)
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Simultaneously, this mitochondrial stress promotes neuroinflammation, which exacerbates damage through extrinsic apoptotic signalingfurther amplifying caspase-3 activation and neuronal loss
