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The contents of DM, CP, OM, NDF, ADF, CF, ADL, EE, and NFC of PC were reported as 18.92% of fresh weight, 22.37% of DM, 90.48%, 35.40%, 24.80%, 17.43%, 5.30%, 1.15%, and 31.57%, respectively [139]

For patients with clinical deficiency, effective replacement therapy should lead to a normal blood count after two months of treatment, while improvement in neurologic symptoms begins within one week after initiation of therapy and is usually complete within 6 weeks to 3 months.13 For patients with an asymptomatic biochemical deficiency (ie, subclinical disease), measurement of serum B12 or MMA levels should be done 2 to 3 months after initiation of replacement therapy.12 Once metformin is started, this medication is seldom discontinued unless advanced renal impairment develops

Time courses typically run 14 to 28 days for tendon endpoints and 60 to 90 days for ligament endpoints

[DOI] [PMC free article] [PubMed] [Google Scholar] 71

Consistency in monitoring prevents recurrence of deficiency