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Ravikumar et al., 2010) reveal abnormal cleavage of PICALM in AD brains, with significantly reduced 75 kDa PICALM levels, disrupted cathepsin D (Cath D) processing, and impaired lysosomal function, leading to autophagy deficits and inhibited Tau degradation

Avissar N, Ornt DB, Yagil Y, Horowitz S, Watkins RH, Kerl EA, et al

These studies have led to significant additional insight into cellular signaling events driving hepatocyte death and liver injury after APAP overdose and will be reviewed in this article