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Disclosure of interest: Nothing to disclose Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.02 - ACUTE MANAGEMENT - Thrombolysis or thrombectomy P666 - ESOC25-2405 BRIDGING INTRAVENOUS THROMBOLYSIS IS ASSOCIATED WITH FASTER RECANALIZATION IN PATIENTS UNDERGOING THROMBECTOMY FOR ISCHAEMIC STROKE DUE TO LARGE ARTERY ATHEROSCLEROSIS Annahita Sedghi 1 , Daniel Kaiser 1 , Witold Polanski 1 , Martin Arndt 1 , Kristian Barlinn 1 , Volker Puetz 1 , Timo Siepmann 1 1 Dresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany Background and Aims: A recent study suggested that bridging intravenous thrombolysis (IVT) for large vessel occlusion LVO may alter clot architecture and facilitate rapid clot removal during thrombectomy, but this may vary by stroke etiology

in particular astrocyte-selective expression of mutated huntingtin with 160 GAG repeats triggered profound down-regulation of EAAT2 and HD-like phenotype in mice

Russell et al., 2017)

It is approved in some other countries as Zadaxin