^ Glutathione-associated Enzymes in Anticancer Drug Resistance1
Also, there is lack of literature evaluating its efficacy.[] IV administered GSH is not directly utilized by cells but is cleaved into its component amino acids and is resynthesized to GSH intracellularly after transmembrane transport
This helps in maintaining the critical protein sulfhydryl level which is considered necessary for DNA repair and protein function
In a 2020 review, the researchers corroborated that silymarin's capacity to reduce oxidative stress on the liver could indeed improve biomarkers associated with conditions such as alcoholic fatty liver disease, nonalcoholic fatty liver disease, alcoholic cirrhosis, and drug-induced liver injury.29 Although the studies covered in the review used 420mg silymarin doses, others have found that amounts as low as 200mg could also impart the desired effects on liver health.30 If that weren't all, a 2018 study concluded that silymarin may actually increase glutathione levels in the liver.31 Selenium (55mcg) Selenium is an essential mineral with antioxidant properties, and one that may increase levels of an enzyme called glutathione peroxidase (GPx).32 GPx is important because it uses reduced glutathione to neutralize hydrogen peroxide,33 one of the major ROS
however, larger studies are still needed to confirm these effects
