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Although PHHs remain the gold standard for in vitro liver models, their availability, variability, and rapid dedifferentiation underscore the values of iHLOs as a scalable, reproducible alternative

If you dosed 5-Amino-1MQ at 8am and it's now 3pm (7 hours), taking MOTS-c still provides some benefit but misses peak NNMT inhibition

1982May;12:313315

Lactate that is produced from an oxygen-independent metabolic pathway (glycolysis) is shuttled to various tissues including muscle, heart, and brain, where it is used as a substrate for oxygen-dependent energy production

Nat Immunol 16:609617 Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, OSullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J et al (2013) Posttranscriptional control of T cell effector function by aerobic glycolysis