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2020b), we conducted a comparative analysis of the liver transcriptome to clearly characterize mitochondrial modulation in our study

However, the presence of conserved helicase motifs does not necessarily implicate unwinding activity that can be detected in vitro 85 , which has been demonstrated for Coronaviridae Nsp13 (53) 86 , Alphaviruses Nsp2 (53) 87 , Flaviviridae NS3 (35) 88,89 , hepatitis E virus ORF1 (53) 90 and others