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The dual action of building new while removing old creates a remodeling effect that simple collagen supplementation cannot achieve

NF-B plays a critical role in the initiation and perpetuation of inflammation

Copper supplementation may mitigate tissue damage during this process (109)

Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients