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In this study, 45 healthy adults with RLS were assigned to receive either standard management of RLS (regimen consisting of eight hours of sleep daily, 20 minutes of mild exercise four times weekly, and vitamin C plus B vitamins) or standard management plus 150 mg Pycnogenol daily for four weeks

Neurotox Res 39 (4):13721380

Travers, J

282 These cytokines sensitize nociceptive neurons, leading to neuropathic pain, and promote neuronal damage through demyelination and axonal degeneration