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Inhibition of these enzymes by xenobiotics, including drugs and botanical products (precipitants), can lead to increased systemic exposure to the object drug and potential adverse or toxic effects

Yam M, Loh Y, Tan C, Khadijah Adam S, Abdul Manan N, Basir R (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation

reported that uptake and cytotoxicity of oxaliplatin increased in HEK293 cells overexpressing rat OCTN1, rat OCTN2, human OCTN1, and human OCTN2, and that OCTN1-mediated transport of oxaliplatin seemed to make a greater contribution to its neuronal accumulation and neurotoxicity compared to OCTN2 or OCTs (Jong et al., 2011)

This treatment is generally well-tolerated and has very few side effects

This negative reaction most often means that you are not allergic to the substance