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The DAC modification allows it to bind to albumin in the blood, dramatically extending its half-life to a matter of days rather than minutes or hours

In some embodiments, the method further comprises repairing said cleaved or nicked target polynucleotide by homologous recombination with an recombination template polynucleotide, wherein said repair results in a mutation comprising an insertion, deletion, or substitution of one or more nucleotides of said target polynucleotide

CD36 activation PPAR- pathway upregulation of anti-inflammatory genes 25-40% reduction in infarct size in rat models of myocardial ischemia-reperfusion

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too much risks overstimulation, desensitization, or adverse side effects