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The mechanism difference (tissue repair via angiogenesis vs gene expression modulation) is exactly what makes them complementary in combination formulations rather than substitutes for each other

& Bode, W

Methimazole and propylthiouracil (PTU) can cause life-threatening agranulocytosis, most commonly within the first few months of therapy, though it can occur later as well

Therefore, GSTP1 gene polymorphism may contribute to the treatment of leukemia

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