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Studies have shown that outer hair cells (OHCs) are the main targets of noise damage, and OHC loss in the basal (high frequency) cochlea is exacerbated [11]

The production of inflammatory cytokines induces the generation of free radicals and alters glutamatergic synaptic transmission in a manner that promotes excitotoxicity [110,111]

We offer a full bioinformatics package including: Site and protein-level annotation Quantitative comparison tables GO/KEGG enrichment of modified proteins Subcellular localization prediction Motif analysis surrounding modification sites Optional protein-protein interaction network mapping All results are provided in user-friendly formats and ready for figure generation

Selective Peptide Cleavage Since end group analysis of large peptides and proteins is of limited value, methods of selectively cleaving such macromolecules into smaller peptide fragments are commonly employed as a major step in structure elucidation