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Mn also decreased the expression of N-methyl-D-aspartate (NMDA) receptors in rats, which also contributed to Mns neurotoxicity in addition to the increased concentrations of extracellular glutamate (Xu et al., 2010a)

PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins

Department of the Army, Washington, DC Litvintseva AP, Marsden-Haug N, Hurst S, Hill H, Gade L, Driebe EM, Ralston C, Roe C, Barker BM, Goldoft M, Keim P (2015) Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection

In the context of lipid metabolism, targeting pathways such as ether lipid synthesis, fatty acid synthase (FASN), or the ACLY/ACC axis has been shown to induce mitochondrial stress and ROS accumulation, thereby enhancing apoptotic responses [144]

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