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This linkage implies that the same may be true for NADPHthat diminished TCA cycle activity might stimulate NADPH production by 1C metabolismthough the enzymes in 1C metabolism that produce NADH and NADPH rely on the same folate derivatives, and it remains unclear whether the cell would prioritize reducing NAD+ over NADP+

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Stanhope KJ, Mirza NR, Bickerdike MJ, Bright JL, Harrington NR, Hesselink MB et al (2001)