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J Mol Biol 433(18):167122

Spalletta S, Flati V, Toniato E, Di Gregorio J, Marino A, Pierdomenico L, et al

published a series of SPS-based PROTACs targeting hematopoietic prostaglandin D synthase (H-PGDS) and BRD4 proteins resulting from the conjugation of different chemical procedures, such as amide coupling chemistry, click-chemistry, and urea formation

G8090, G8091, G8093, G8092

E2 is principally synthesized by ovaries, corpus luteum and placenta but it is also produced by other tissues such as the brain, adipose tissue, bone, vascular endothelium, and aortic smooth muscle cells [5]