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Validation of the experimental model The RT-qPCR analyses revealed distinctive transcriptional signatures for MOD and SEV forms of COVID-19 and the CTRL group in the aliquots of endpoint Z, which remained mostly preserved after 24h of incubation (endpoint A) ( Figure S2 and Figure 3 )

Consequently, their usage in individuals with impaired glucose metabolism, such as those with diabetes, should be restricted or closely monitored [115] (Table 1)