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Exploring the underlying mechanisms of these effects shows that bergamot is able to decrease the expression of SREBP-1c and SREBP-2 in hepatic tissues (106)

Although several preclinical anti-cancer outcomes have been achieved, such as with ferroptosis inducers, translating oxidative cell death mechanisms into effective clinical therapies requires rigorous testing, including assessments of bioavailability, toxicity, and off-target effects

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Antiangiogenesis as a therapeutic approach led to renewed interest in cilengitide

J Comp Pathol Therap 60:177189 Blaxter KL, Allcroft R (1950) Lead as a nutritional hazard to farm animals: I