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In melanocytes 4-HNE, through adduct formation, alters protein function, contributing to oxidative stress-induced cellular dysfunction, which mainly concerns on the functioning of cellular antioxidant system, acceleration of protein degradation, inhibition of melanocyte proliferation, photoaging processes, but also disruption of the intercellular interactions between melanocytes and keratinocytes 101,102,103

Springer, New York, pp 2132 Lucas GNC, Leito ACC, Alencar RL, Xavier RMF, Daher EDF, Silva Junior GBD (2019) Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

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