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For example, there are at least 6 major classes of MHC genes identified as important in transplant biology in humans

Front Cell Dev Biol 9:3861 Zhao T, Guo X, Sun Y (2021) Iron accumulation and lipid peroxidation in the aging retina: implication of ferroptosis in age-related macular degeneration

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Then this interleukin binds CD8+ NKG2D+ T cells to further stimulate IFN- production through JAK1 and JAK3 pathways, forming a positive feedback loop (Figure 1) that destroys anagen hair follicles and leads to alopecia areata (34)