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Further, Geniposide (GE), an iridoid glycoside from Gardenia Jaminoides , was found to promote Nrf2 transcriptional activation in HFpEF mice, alleviate oxidative stress in H9c2 and HL-1 cells, and reduce oxidative damage brought on by H2O2 using the MMP2/SIRT1/GSK3 pathway (Han Y.-L

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Neuroprotection is mediated by a multiplicity of biochemical targets and pathways including inflammation control, apoptosis control, and the regulation of oxidative stress

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