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Researchers should either use a higher concentration (5mg/mL or 6mg/mL, achievable with 20mg or 30mg vials) or split the weekly dose across two injection sites on the same day

Do not breastfeed during treatment with pemetrexed for injection and for 1 week after the last dose

If a breastfeeding infant experiences an adverse effect related to a maternally administered drug, healthcare providers are encouraged to report the adverse effect to the FDA