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CKD affects at least 10-16% of adults around the world

40 In line with previous reports, we revealed that DATS (25 M) was more effective than DADS and DAS in decreasing cell viability of A375 and BCC cells

Cell Metab 15(4):518533

However, most of the population, particularly in third-world nations, cannot afford the long-term use of these drugs

3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )