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The role of insulin-like growth factor binding proteins in metabolic syndrome Recall that IGFBPs have a very important role, not only in modulating free IGF-1, half-life and localisation, but also by possessing IGF-independent activities mediated by their own receptors

if B12 levels were either at the high end of acceptable range, or higher than acceptable range, then the recommendation also included advice to review the frequency of the intervention and to consider changing from 3-monthly interventions to 6-monthly interventions

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