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10 ChiY.ChengY.VanithaJ.KumarN.RamamoorthyR.RamachandranS.et al (2011)

Distilled water was replaced every 30 days during the 180-day observation period

This finding has been reinforced by using pharmacologic inhibitors of PPP, 6-aminonicotinamide or dehydroepiandrosterone (DHEA) in both vitro and in vivo studies (61)

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Molecular basis of differences in (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat kappa-opioid receptors expressed in Chinese hamster ovary cells