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For protein expression, a GPX4-pTT5 plasmid together with the SBP2-pTT5 was expressed transiently in HEK293-6E cells

EClinicalMedicine 34 , 100797 (2021)

This suggests that the pharmacological actions of heroin somewhat antagonize those of 6-MAM, at least for what concern dopamine release in the rat striatum

In addition, in the case of energy depletion, these transporters can function in the reversed mode and thus contribute to glutamate release as also mentioned above