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Ginsenoside Rb1 alleviates alcohol-induced liver injury by inhibiting steatosis, oxidative stress, and inflammation

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The two human 3-hydroxysteroid dehydrogenases have been investigated in detail by Thomas and coworkers (e.g., Thomas et al., 2005), and their studies indicate that the 3-ketosteroid 5-AD formed by oxidation of dehydroepiandrosterone with NAD + as a coenzyme remains as an intermediate bound to the enzyme prior to its isomerization to 4-AD