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Description

Microscopic analysis of intestinal tissue from IBD patients reveals a decrease in goblet cells (50), reduction thickness of mucus layer, and defective defensin production (310), with an altered composition of some components such as mucins and phosphatidylcholine (311)

Firstly, at the molecular expression level, TMAO can significantly up-regulate the expression of MHC-II molecules and co-stimulatory molecules CD86 on the surface of DCs

Our aim was to develop a representative in vitro model of HT1 using human induced pluripotent stem cell (iPSC) and assess the effect of NTBC treatment