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Sci Adv 2023;9:eade9585

Icariin could promote the process of osteoblast survival and reverse the downregulation of the expression of Runx2, alkaline phosphatase (ALP), and osteopontin (OPN) (induced by iron overload), and this effect could be attributed to the protection against mitochondrial membrane potential dysfunction and ROS production (Jing et al., 2019)