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A randomized, placebo-controlled clinical trial showed that 500 mg of passionflower decreases anxiety before surgery.[ref] Another clinical trial also showed passionflower to be equal to oxazepam, a benzodiazepine, for generalized anxiety disorder.[ref] Kava Kava: Piper methysticum, or kava, is a traditional South Pacific medicinal plant that decreases anxiety by enhancing binding to GABA-A receptors and also blocking excitatory neurotransmitters

The two are frequently paired, which is why a combined blend exists

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IJVAR 3(1):69 Ugur AR, Dagi HT, Ozturk B, Tekin G, Findik D (2016) Assessment of in vitro antibacterial activity and cytotoxicity effect of Nigella sativa oil

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