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Pyroglutamic acid (PCA), also known as 5-oxoproline, is a cyclic derivative of glutamic acid (or glutamine) and a gamma-glutamyl cycle metabolite indicative of glutathione turnover [149]

The handling Editor declared a shared affiliation, though no collaboration, with three of the authors, ZL, JQ, and JC, at the time of review

More recently, a randomized, double-blind, 24-week cross-over trial in 63 adults suffering from migraines found that 500 mg/day of magnesium oxide was equally effective as sodium valproate for reducing the migraine frequency and duration over the eight-week treatment period (194)

More recent studies suggest that the blood concentration of trimethylamine N-oxide (TMAO), generated from trimethylamine-containing nutrients like dietary choline, rather than that of choline, might influence the risk of cardiovascular events (see Safety)

Moreover, a substantial methodological heterogeneity, including inconsistent protocols, lack of blinding, and unclear randomisation, limits the robustness of the conclusions