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Description

Compound 9 (Figure 12) was found to be a highly effective and selective COX-2 inhibitor (COX-2 IC 50 = 0.23 M

A1 receptor activation tamps down the excited state of the neurons by modulating ion channels proteins in the cell membrane that allow passage through the cell of other proteins which help generate electrical signals

We aimed to investigate gene expression dynamics in experimental SAH, by comparing them to sham rats at different time points to identify potential novel therapeutic targets