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Abstract Late-life depression (LLD), a growing public health challenge in aging societies, profoundly impacts physical and mental health by exacerbating cognitive decline, functional disability, and comorbid chronic diseases

It adds a different operational layer

As a result, it has been shown to raise red blood cell folate more effectively and lower homocysteine more than equivalent doses of folic acid

In patients with chronic obstructive pulmonary disease (COPD), CLA supplementation at a dose of 3.2 g/day for 6 weeks (c9, t11, and c12, t10 isomers in a 50/50 ratio) demonstrated a reduction in serum oxidative stress-related factors, including MDA and matrix metalloproteinase-9 (MMP-9), compared to the placebo group [27], The study suggested that these antioxidant effects were likely a result of the anti-inflammatory properties of CLA, which partly occur through the stimulation of peroxisome proliferator-activated receptors [27]

SLE with childhood onset (up to 18 y of age)