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Activated macrophages (M1 type macrophages) invade the synovium, and the imbalanced ratio of M1 type and anti-inflammatory macrophages (M2 type) in synovial tissues as well as the differentiation of macrophage precursor cells into osteoclasts are important characteristics of RA (203)

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Prevalence of cerebral folate deficiency is estimated to be between 1/4000 and 1/6000 children, although the disorder is probably underdiagnosed (44)

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To better understand the advantages and limitations of herbal treatments relative to existing therapies, future research should actively incorporate such comparative experiments, offering more reliable data support for clinical decision-making