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CYP3A4 induction also leads to consequent generation of acetaldehyde and lipid peroxidation-derived protein-aldehyde adducts in the liver (Niemel et al., 2000), which are hybrid compounds resulting by interaction of alcohol metabolites with other complex molecules, confirming previous findings in the liver of alcohol-treated rats (Niemel et al., 1998)

Similarly, quercetin has been reported to protect against the iron induced depletion in the glutathione in rat kidney [72]

Galluzzi L, Kroemer G

As a result, soluble CD163 (sCD163) and microglia-bound CD163 could, theoretically, sequestrate hemoglobin and reduce the inflammatory and toxic effects of hemoglobin and iron on neurons [112,113,114]

doi: 10.3390/antiox12112016 131